Is melanopsin activation affecting large field color-matching functions?

Color theory is based on the exclusive activation of cones. However, since the discovery of melanopsin expressing cells in the human retina, evidence of its intrusion in brightness and color vision is increasing. We aimed to assess if differences between peripheral or large field and foveal color matches can be accounted for by melanopsin activation or rod intrusion. Photopic color matches by young observers showed that differences between extrafoveal and foveal results cannot be explained by rod intrusion. Furthermore, statistical analyses on existing color-matching functions suggest a role of melanopsin activation, particularly, in large field S fundamentals.

Dynamics of Visual Adaptation With Simultaneous Stimulation of Two Visual Pathways.

Primates' retinal ganglion cells in different visual pathways have been shown to adapt independently (Current Biology 22 (2012) 220-224). However, the manner in which adaptation occurs under simultaneous stimulation of two visual pathways has not yet been explored. In this study, the dynamics of color afterimages were measured while stimulating one or two visual pathway using a time-varying afterimage paradigm. The dynamics of adaptation was approximately equivalent among the three primary visual pathways, but adaptation was slower for simultaneous stimulation of two visual pathways compared to the stimulation of one visual pathway. In addition, we found that the speed of adaptation also depends upon which two pathways are combined. We developed a two-stage adaptation model, both with the same dynamics, to account for the results with simultaneous stimulation of two pathways.

Quantifying the effect of straylight on photopic contrast sensitivity.

The visual performance of a reference group (RG) using diffuser filters was compared to a cataract-diagnosed group (CatG). Measurements of straylight (SL) parameter, photopic contrast sensitivity (CS), and visual acuity (VA) were carried out in both groups. Before the analysis, the performance of the instruments used for this purpose was tested. The RG was comprised of three healthy, young eyes (25-30 years old) while 59 subjects (aged 50-80 years old) with lens opacities were recruited for the CatG. Six diffuser conditions were tested in the RG. To discriminate between light scattering levels, SL measurements proved to be most sensitive, VA did not discriminate at all, while CS showed intermediate sensitivity. VA was not correlated with SL, while the correlation between CS and SL was significant (p<0.05) in both groups. Since the correlation in the RG was particularly strong, parameters of a linear regression model are presented. The behavior of CS as a function of SL was comparable to some extent between RG and CatG.

Straylight and Visual Quality on Early Nuclear and Posterior Subcapsular Cataracts.

PURPOSE: To measure log(s) and OSI parameters, both related to forward light scattering in the eye, in subjects with different kinds of early cataracts-nuclear or posterior subcapsular-and corrected visual acuity (CVA). METHODS: 34 eyes of 19 patients ranged between 50 and 75 years old with diagnosed nuclear (14 eyes) or posterior subcapsular cataract (20 eyes) were recruited. Only NO1, NO2, P1, and P2 opacity scores according to LOCS III were included. Observer examination included visual acuity, contrast threshold (Ct), and measurements performed by straylightmeter (straylight parameter log(s)) and double-pass instrument (objective scatter index (OSI)). RESULTS: OSI and log(s) were correlated with LOCSIII in nuclear opacities (p = 0.015 and 0.004, respectively) and in the whole data (p = 0.027 and 0.019, respectively) but did not for posterior subcapsular opacities alone. OSI was strongly correlated with log(s) in nuclear (r = 0.885 and p < 0.001) but not in posterior subcapsular cases (r = 0.382 and p = 0.097). Ct was correlated with log(s) for both cataract types (p = 0.043 for nuclear and p= 0.005 for posterior subcapsular cataract) but not with OSI (p = 0.093 for nuclear and p = 0.064 for posterior subcapsular cataract). CONCLUSIONS: OSI and log(s) discriminate early stages of nuclear cataracts when taking LOCS III as reference, so these opacities could be graded by any of those parameters. LOCSIII does not represent the visual condition for posterior subcapsular cataract. Straylightmeter measurements express the loss in contrast sensitivity caused by nuclear and posterior subcapsular opacities. Studies of lens opacities must be separated according to the type of opacity present in eyes.